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Be cool to be far: Exploiting hibernation for space exploration.
Matteo Cerri1, Timna Hitrec1, Marco Luppi1
1Department of Biomedical and NeuroMotor Sciences, Alma Mater Studiorum -University of Bologna, Piazza di Porta S.Donato, 2 40126, Bologna, Italy.
Neuroscience and Biobehavioral Reviews
|June 18, 2021
Summary
Synthetic torpor, a hibernation-like state, can be induced in mammals by targeting specific brain pathways. This offers potential benefits for medical applications and space exploration, including radiation protection.
Area of Science:
- Neuroscience
- Physiology
- Astrobiology
Background:
- Mammalian torpor/hibernation involves reduced metabolic rate and body temperature.
- This state is crucial for survival in harsh environmental conditions.
Purpose of the Study:
- To explore the induction of synthetic torpor in non-hibernating mammals.
- To evaluate the potential of synthetic torpor for medical and space exploration applications.
Main Methods:
- Inhibiting neurons in the Raphe Pallidus brainstem region.
- Activating adenosine A1 receptors in the brain.
Main Results:
- Successfully mimicked torpor in non-hibernators.
- Identified specific neural pathways and receptors for torpor induction.
Conclusions:
- Synthetic torpor is achievable through targeted neural manipulation.
- This state holds promise for medical treatments and enhancing astronaut protection from cosmic rays during space travel.
- Further in-orbit testing, such as on the International Space Station, is recommended to assess physiological advantages.
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