Magnesium-L-threonate alleviate colonic inflammation and memory impairment in chronic-plus-binge alcohol feeding mice

Magnesium-l-threonate (MgT) is considered a food supplement. Alcohol-mediated diseases (AMD) are accompanied by inflammation and memory impairment. The purpose of this study is to investigate the function of MgT in AMD. Hence, chronic-plus-binge alcohol feeding mice model and multiply bioinformatics analysis were performed. Consequently, the expression of inflammatory cytokines downregulated, while the activities of antioxidases decreased in serum, colon, and brain. Interestingly, MgT relieved gut barrier dysfunction and reshaped microbiota. The relative abundance of Akkermansia, Odoribacter, and Blautia were increased, while that of Alloprevotella and Clostridium were decreased. Metabolic analysis elucidated amino acids and glutamate metabolism were enhanced in MgT-treated mice. Furthermore, morris water maze test confirmed memory ability was enhanced. Inflammation cytokines were negatively correlated with Blautia, and Akkermansia. Collectively, MgT relieved inflammation in gut-brain axis of mice, reshaped gut microbiota, and enhanced the amino acids and glutamate metabolism. MgT may be used as a food supplement to prevent inflammation and memory impairment induced by alcohol abuse.