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Updated: Nov 1, 2025

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Published on: August 30, 2018
Pharmacokinetics of meropenem during advanced organ support (ADVOS®) and continuous renal replacement therapy
Christina König1,2, Stefan Kluge1, Valentin Fuhrmann1,3
1Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Abstract:
The advanced organ support (ADVOS) system allows to eliminate water-soluble as well as protein-bound molecules. Despite its clinical features, to date nothing is known about the elimination of clinically relevant drugs such as antiinfectives. Therefore, we report a case treated with ADVOS, continuous renal replacement therapy (CRRT), and meropenem (1 g 8-hourly) for empiric sepsis therapy monitored by meropenem drug levels. ADVOS showed more efficient elimination of meropenem compared to CRRT which has to be considered when evaluating dosing regimens.
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