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Updated: Nov 1, 2025

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
Published on: June 13, 2014
[New therapeutic strategies in HER2-positive breast cancer]
Benoîte Mery1, Philippe Toussaint1, Pierre-Etienne Heudel1
1Centre Léon-Bérard, département de cancérologie médicale, 28, rue Laennec, 69008 Lyon, France.
Abstract:
Breast cancer with HER2-amplification accounts for 20% of breast cancers. The management of patients has dramatically changed with the advent of anti-HER2 treatment, especially the monoclonal antibodies since 2000 in the metastatic and (neo)-adjuvant setting, leading to an improvement of patient outcomes. If therapeutic arsenal has been gradually enhanced with the targeting of HER receptors family, resistances to these treatments are observed, hence the development of new therapeutic strategies. This review provides an updated look of novel therapeutic strategies in HER2-positive breast cancer, as well as future perspectives, both in the adjuvant and metastatic setting.
Insights
Novel treatments are emerging for HER2-positive breast cancer, offering new hope against treatment resistance. This review explores advanced therapeutic strategies and future directions for improved patient outcomes.
Area of Science:
- Oncology
- Molecular Biology
- Pharmacology
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