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Updated: Nov 1, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Apalutamide-induced severe interstitial lung disease: A report of two cases from Japan
Hiroshi Kobe1, Ryo Tachikawa2, Yoshitsugu Masuno2
1Department of Respiratory Medicine, Kobe City Medical Center General Hospital, 2-1-1 Minatojima-minaminachi, Kobe City, Hyogo, 650-00047, Japan; Department of Respiratory Medicine, Ohara Healthcare Foundation, Kurashiki Central Hospital, Kurashiki City, Okayama, 710-8602, Japan.
Abstract:
Apalutamide, a competitive inhibitor of the androgen receptor, is being increasingly used for the treatment of prostate cancer. There have been few reports of interstitial lung disease in clinical trials of apalutamide. However, two cases of apalutamide-induced interstitial lung disease with respiratory failure in Japanese males, who were successfully treated with high-dose corticosteroids, are presented here. These cases suggest that clinicians should be alert to the potentially life-threatening risk of pulmonary toxicity associated with apalutamide treatment.
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