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Coronavirus Disease-2019 in Children with Primary Kidney Disease: A Case series

Ashwin Meshram1, Kinnari B Vala1, Anshuman Saha1

  • 1Department of Rediatric Nephrology, Institute of Kidney Diseases and Research Center, Ahmedabad, Gujarat, India.

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia
|June 19, 2021
PubMed

Insights

Children with primary kidney disease experienced mild to moderate coronavirus disease-2019 (COVID-19). Prompt management with azithromycin and supportive care led to full recovery in these pediatric patients.

Area of Science:

  • Pediatric Nephrology
  • Infectious Diseases
  • Public Health

Background:

  • Comorbid illnesses are recognized risk factors for severe COVID-19.
  • The clinical presentation of COVID-19 in pediatric patients with primary kidney disease remains unclear.

Observation:

  • This study details the clinical profile and management of three children with primary kidney disease (nephrotic syndrome, hemolytic uremic syndrome, chronic kidney disease) diagnosed with COVID-19.
  • Two immunosuppressed patients temporarily halted immunosuppressants and experienced mild illness.
  • One patient with chronic kidney disease presented with moderate illness requiring oxygen support.

Findings:

  • All three pediatric patients maintained normal renal function throughout their COVID-19 illness.
  • Treatment with oral azithromycin and supportive care resulted in complete recovery for all patients.
  • No patients required chloroquine, corticosteroids, or monoclonal antibodies.

Implications:

  • COVID-19 in children with primary kidney disease may have a manageable clinical course.
  • Azithromycin and supportive care appear effective for treating COVID-19 in this vulnerable pediatric population.
  • Further research is warranted to understand long-term outcomes and optimal management strategies.

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