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Related Experiment Videos

Vascular sympathetic nerve function in congestive heart failure.

R Zelis1, H Brunner, K Zelis

  • 1Division of Cardiology, Pennsylvania State University, College of Medicine, Milton S. Hershey Medical Center, Hershey 17033.

The American Journal of Cardiology
|September 9, 1988
PubMed
Summary
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In congestive heart failure, rats with heart damage did not show intrinsic sympathetic nerve defects in pulmonary arteries. Increased nerve activity or reduced norepinephrine clearance are likely causes of higher norepinephrine levels.

Area of Science:

  • Cardiovascular Physiology
  • Neuropharmacology
  • Heart Failure Pathophysiology

Background:

  • Congestive heart failure is associated with increased sympathetic nerve activity and elevated plasma norepinephrine levels.
  • The contribution of intrinsic sympathetic nerve abnormalities within the vasculature to enhanced vascular tone in heart failure remains unclear.

Purpose of the Study:

  • To investigate whether intrinsic abnormalities in sympathetic nerve function of pulmonary arteries contribute to enhanced vascular tone in a rat model of congestive heart failure.

Main Methods:

  • Chronic myocardial infarction was induced in rats via coronary artery ligation.
  • Excised pulmonary arteries were superfused with 3H-norepinephrine and stimulated electrically at varying frequencies (2, 4, 8, 16 Hz).
  • 3H-norepinephrine overflow was measured to assess sympathetic nerve function.

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Main Results:

  • Electrically evoked 3H-norepinephrine overflow was similar between sham and infarct vessels at most frequencies.
  • However, infarct vessels showed a significant reduction in 3H overflow at the highest frequency (16 Hz).
  • Frequency-response curves for infarct vessels shifted leftward, suggesting increased sympathetic nerve sensitivity.

Conclusions:

  • Intrinsic sympathetic nerve abnormalities in pulmonary arteries are unlikely to be the primary cause of elevated plasma norepinephrine in congestive heart failure.
  • Increased sympathetic nerve activity or reduced norepinephrine clearance are more probable explanations for heightened vascular tone in this condition.