Recent Advances in 3D Printing for Parenteral Applications
Ryan Ivone1, Yan Yang2, Jie Shen3,4
1Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, 7 Greenhouse Road, Kingston, Rhode Island, 02881, USA.
The AAPS Journal
|June 19, 2021
Summary
3D printing offers personalized parenteral medicines, including wound dressings and regenerative therapies. Research is expanding to address challenges in sterilization and regulatory approval for these advanced applications.
Area of Science:
- Pharmaceutical Sciences
- Biomedical Engineering
- Materials Science
Background:
- 3D printing is an advanced manufacturing technology with significant pharmaceutical applications.
- Current research predominantly focuses on enteral drug delivery systems.
- Parenteral applications, including wound dressings, biomedical devices, and regenerative medicines, remain underexplored.
Purpose of the Study:
- To highlight the potential of 3D printing for parenteral applications.
- To discuss the impact of printing parameters and material selection on construct properties.
- To identify challenges and future directions for 3D printing in parenteral medicine.
Main Methods:
- Review of existing literature on 3D printing technologies (fused deposition modeling, vat polymerization, powder bed printing) in pharmaceutical sciences.
- Analysis of how printing properties and material selection influence printability, drug release, and mechanical characteristics.
- Identification of challenges such as sterilization, post-processing, and regulatory hurdles.
Main Results:
- 3D printing enables rapid prototyping of personalized parenteral dosage forms with patient-specific dimensions and porosity.
- Printing parameters and material choice critically affect construct printability, drug release kinetics, and mechanical integrity.
- Key challenges include effective sterilization, post-printing modifications, and the need for clear regulatory pathways.
Conclusions:
- 3D printing holds significant promise for developing personalized parenteral medicines and advanced biomedical applications.
- Further research and development are needed to overcome technical and regulatory obstacles.
- Continued evolution of 3D printing technologies will drive innovation in parenteral drug delivery and regenerative therapies.
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