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Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease
Published on: October 4, 2021
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Non-Invasive Sweat-Based Tracking of L-Dopa Pharmacokinetic Profiles Following an Oral Tablet Administration
Jong-Min Moon1, Hazhir Teymourian1, Ernesto De la Paz1
1Department of Nanoengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
Angewandte Chemie (International Ed. in English)
|June 19, 2021
Summary
This study introduces a novel, non-invasive method to monitor Levodopa (L-Dopa) levels in Parkinson disease patients using fingertip sweat. This personalized approach tracks drug concentrations dynamically, correlating sweat levels with blood plasma for optimized treatment.
Area of Science:
- Biomedical Engineering
- Neuroscience
- Analytical Chemistry
Background:
- Levodopa (L-Dopa) is the primary treatment for Parkinson disease (PD) symptoms.
- Long-term L-Dopa use leads to motor and non-motor complications due to fluctuating plasma levels and disease progression.
Purpose of the Study:
- To develop and validate the first individualized therapeutic drug monitoring approach for L-Dopa.
- To utilize fingertip sweat for dynamic, non-invasive tracking of L-Dopa concentration.
Main Methods:
- A touch-based, non-invasive detection method using fingertip sweat.
- Instantaneous sweat collection on a hydrogel for transport to a tyrosinase-modified electrode.
- Electrochemical measurement of L-Dopa via dopaquinone reduction.
Main Results:
- Demonstrated a personalized dose-response relationship for L-Dopa in human subjects.
- Established a strong pharmacokinetic correlation between fingertip sweat L-Dopa and capillary blood L-Dopa levels.
Conclusions:
- Fingertip sweat analysis offers a viable, non-invasive method for personalized L-Dopa therapeutic drug monitoring in Parkinson disease.
- This approach may help mitigate L-Dopa-associated complications by enabling precise dose adjustments.
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