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Metabolic regulation in the immune response to cancer

Qi Wu1, Xin Yu1, Juanjuan Li1

  • 1Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, P. R. China.

Cancer Communications (London, England)
|June 19, 2021
PubMed

Insights

Metabolic reprogramming significantly impacts cancer progression and immune response. Targeting metabolites offers a promising strategy to enhance cancer treatments and immunotherapy effectiveness.

Area of Science:

  • Oncology
  • Immunology
  • Metabolism

Background:

  • Tumor-immune interactions involve metabolic reprogramming, influencing cancer development and immune evasion.
  • Dysregulated metabolites and their regulators are critical in cancer progression and treatment outcomes.

Purpose of the Study:

  • To elucidate the molecular mechanisms of how metabolites influence host immune responses in cancer.
  • To explore the interplay between metabolism, immunity, and cancer progression.

Main Methods:

  • Review and synthesis of current literature on metabolic reprogramming in cancer.
  • Focus on mechanistic insights into metabolite-mediated immune modulation.

Main Results:

  • Identified microenvironmental, systemic, and microbial metabolites as key modulators of anti-cancer immunity.
  • Detailed the complex interactions between metabolic pathways and immune cell functions in the tumor microenvironment.

Conclusions:

  • Metabolic interventions present a viable strategy to augment conventional and immunotherapeutic cancer treatments.
  • Targeting metabolic pathways can potentially overcome resistance and improve patient outcomes in oncology.
Keywords:
agingcancerimmune responsemetabolismmicrobesobesity

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