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Functional roles of non-coding RNAs in atrophy
Soudeh Ghafouri-Fard1, Atefe Abak2, Shiva Khademi3
1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Summary
This review explores how non-coding RNAs (ncRNAs), specifically long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), contribute to atrophy, a condition impacting cell and tissue size in various diseases.
Area of Science:
- Molecular Biology
- Cell Biology
- Pathophysiology
Background:
- Atrophy, a decrease in cell, organ, or tissue size, is linked to numerous human disorders.
- Causes include poor nutrition, circulation, hormonal imbalance, nerve defects, apoptosis, and lack of exercise.
- Non-coding RNAs (ncRNAs) are increasingly recognized for their role in regulating atrophy.
Purpose of the Study:
- To review the role of non-coding RNAs in atrophy-associated disorders.
- To focus on long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in this context.
Main Methods:
- Literature review of studies investigating ncRNAs and atrophy.
- Focus on lncRNAs and miRNAs involved in age-related muscle atrophy, neurodegenerative diseases, and cardiac atrophy.
Main Results:
- ncRNAs, including lncRNAs and miRNAs, play a significant role in the pathogenesis of atrophy.
- These molecules are implicated in conditions like neurodegenerative/neuromuscular diseases and age-related muscle atrophy.
Conclusions:
- lncRNAs and miRNAs are key regulators in atrophy.
- Understanding their mechanisms is crucial for developing therapeutic strategies for atrophy-related conditions.
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