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Thymidylate synthase is essential for efficient HIV-1 replication in macrophages

Vincent Desrosiers1, Corinne Barat1, Yann Breton1

  • 1Axe des Maladies Infectieuses et Immunitaires, Centre de Recherche Du CHU de Québec-Université Laval, Pavillon CHUL, Québec, QC, G1V 4G2, Canada.

Virology
|June 19, 2021
PubMed
Summary

Thymidylate synthase (TS) is vital for HIV-1 replication in macrophages. Inhibiting TS reduces viral infection by impacting early viral cycle steps, suggesting TS as a therapeutic target.

Keywords:
HIV-1MDMsNucleotidesReverse transcriptionThymidine synthase

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