RSF1 in cancer: interactions and functions.

Area of Science:

• Molecular Biology
• Cancer Biology
• Genetics

Background:

• Remodelling and spacing factor 1 (RSF1) is a centromere protein implicated in cancer progression.
• RSF1 overexpression correlates with poor patient survival across various cancer types.
• RSF1's dual role involves maintaining genomic stability at optimal levels but promoting cancer survival when overexpressed.

Purpose of the Study:

• To review the functional domains and overexpression status of RSF1 in cancer.
• To elucidate the cancer-related functions of RSF1 through its interactions with key proteins.
• To explore the clinical potential of targeting RSF1 and SNF2H in cancer therapy.

Main Methods:

• Analysis of RSF1 and SNF2H expression using TCGA and GTeX databases.
• Review of literature on RSF1's interactions with proteins including H2Aub, HDAC1, CENP-A, PLK1, ATM, CENP-S, SNF2H, HBx, BubR1, cyclin E1, CBP, and NF-κB.
• Summary of RSF1's functional domains and cancer-specific roles.

Main Results:

• RSF1 is frequently overexpressed in diverse cancers, linked to poor prognosis.
• RSF1 overexpression contributes to drug resistance and cell cycle deregulation, fostering cancer growth.
• RSF1 interacts with multiple proteins involved in chromosome stability, DNA repair, and oncogenic pathways.

Conclusions:

• RSF1 expression levels and cellular context dictate its function in cancer.
• Understanding RSF1's interactions provides a basis for developing targeted therapies.
• Inhibitors of RSF1, its truncated forms, or SNF2H hold promise for treating RSF1-overexpressing tumors.