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RSF1 in cancer: interactions and functions

Guiyang Cai1, Qing Yang2, Wei Sun3

  • 1Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.

Cancer Cell International
|June 20, 2021
PubMed

Insights

Remodelling and spacing factor 1 (RSF1) is overexpressed in many cancers, promoting proliferation and drug resistance. Targeting RSF1 or SNF2H may offer new cancer treatment strategies.

Area of Science:

  • Molecular Biology
  • Cancer Biology
  • Genetics

Background:

  • Remodelling and spacing factor 1 (RSF1) is a centromere protein implicated in cancer progression.
  • RSF1 overexpression correlates with poor patient survival across various cancer types.
  • RSF1's dual role involves maintaining genomic stability at optimal levels but promoting cancer survival when overexpressed.

Purpose of the Study:

  • To review the functional domains and overexpression status of RSF1 in cancer.
  • To elucidate the cancer-related functions of RSF1 through its interactions with key proteins.
  • To explore the clinical potential of targeting RSF1 and SNF2H in cancer therapy.

Main Methods:

  • Analysis of RSF1 and SNF2H expression using TCGA and GTeX databases.
  • Review of literature on RSF1's interactions with proteins including H2Aub, HDAC1, CENP-A, PLK1, ATM, CENP-S, SNF2H, HBx, BubR1, cyclin E1, CBP, and NF-κB.
  • Summary of RSF1's functional domains and cancer-specific roles.

Main Results:

  • RSF1 is frequently overexpressed in diverse cancers, linked to poor prognosis.
  • RSF1 overexpression contributes to drug resistance and cell cycle deregulation, fostering cancer growth.
  • RSF1 interacts with multiple proteins involved in chromosome stability, DNA repair, and oncogenic pathways.

Conclusions:

  • RSF1 expression levels and cellular context dictate its function in cancer.
  • Understanding RSF1's interactions provides a basis for developing targeted therapies.
  • Inhibitors of RSF1, its truncated forms, or SNF2H hold promise for treating RSF1-overexpressing tumors.
Keywords:
CENP-AH2AubNF-κBPLK1RSF1SNF2H

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