Related Experiment Video
Updated: Nov 1, 2025
02:49
Author Spotlight: A Multi-Depth Porcine Model for Comprehensive Study of Burn Injuries and Healing Processes
Published on: February 23, 2024
1.6K
Effects of ginsenoside Rb1 on second-degree burn wound healing and FGF-2/PDGF-BB/PDGFR-β pathway modulation
Li Zhang1, Qin Hu1, Haonan Jin1
1School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, 1168 West Chunrong Road, Chenggong, Kunming, Yunnan, 650500, PR China.
Chinese Medicine
|June 20, 2021
Summary
Ginsenoside Rb1, derived from Panax notoginseng, significantly accelerates burn wound healing in rats. This effect is linked to increased expression of FGF-2, PDGF-BB, and PDGFR-β, promoting faster skin tissue repair.
Area of Science:
- Pharmacology and Traditional Chinese Medicine
- Wound Healing Research
- Biochemistry and Molecular Biology
Background:
- Panax notoginseng is a traditional Chinese medicine used for various ailments, including injuries.
- Ginsenoside Rb1, a key component of P. notoginseng, shows potential anti-inflammatory and cell growth-promoting properties.
- This study investigates the efficacy of ginsenoside Rb1 in treating burn wounds.
Purpose of the Study:
- To evaluate the therapeutic effects of ginsenoside Rb1 on second-degree burn injuries in a rat model.
- To explore the underlying molecular mechanisms of ginsenoside Rb1 in promoting burn wound healing.
Main Methods:
- Established a second-degree burn model in rats.
- Monitored wound healing macroscopically and histologically (HE staining).
- Assessed protein and mRNA expression of PDGF-BB, PDGFR-β, and FGF-2 using IHC, WB, and RT-PCR.
Main Results:
- Ginsenoside Rb1 treatment improved skin tissue morphology and accelerated scab removal and fur regrowth.
- Wound healing rate was significantly increased in the treatment group.
- Expressions of PDGF-BB, PDGFR-β, and FGF-2 peaked earlier in ginsenoside Rb1-treated rats.
Conclusions:
- Ginsenoside Rb1 effectively promotes burn wound healing in rats.
- The mechanism involves the upregulation of FGF-2/PDGF-BB/PDGFR-β gene and protein expressions.
- Ginsenoside Rb1 shows promise as a therapeutic agent for burn injuries.
Related Concept Videos
01:19Clinical Applications of Epidermal Stem Cells
2.9K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.9K
01:22Burn Injuries
3.2K
Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
3.2K
01:16TGF - β Signaling Pathway
8.2K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
8.2K
01:19Overview of Regeneration and Repair
4.4K
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
Regeneration
All animals have varying degrees of...
4.4K