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Updated: Nov 1, 2025

Study of Protein-protein Interactions in Autophagy Research
Published on: September 9, 2017
Non-canonical functions of autophagy proteins in immunity and infection
1Viral Immunobiology, Institute of Experimental Immunology, University of Zurich, Switzerland.
Abstract:
The molecular machinery of macroautophagy, a catabolic pathway for cytoplasmic constituent degradation in lysosomes, remodels membranes by lipid phosphorylation and conjugation of LC3 and GABARAP proteins. In recent year it has become clear that these membrane modifications also regulate endo- and exocytosis. Here I will discuss recent evidence of how such non-canonical functions of the macroautophagy machinery with its autophagy related gene (atg) products influences infectious viral particle secretion, inflammation, and MHC restricted antigen presentation. Especially LC3-Associated Phagocytosis and ATG supported exocytosis will be high-lighted during immunity and infection.
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