Osteoprotegerin changes in saliva and serum of patients with knee osteoarthritis
M-R Mirzaii-Dizgah1, M-H Mirzaii-Dizgah2, I Mirzaii-Dizgah3
1Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Objective:
The scope of this study was to assess salivary and serum osteoprotegerin (OPG) levels in knee osteoarthritis (OA).
Methods:
Serum and saliva OPG levels of 30 knee OA and 30 matched healthy controls in this cross-sectional study was assessed by ELISA. Knee pain was assessed by WOMAC. Data were analyzed by Student's t-test, Spearman correlation test and ROC.
Results:
The mean serum but not saliva OPG level was lower in knee OA than that of the healthy group. WOMAC negatively correlated with serum OPG (r = -0.501; P = 0.000). The serum OPG cutoff value was 237.5 pg/ml for the diagnosis of knee OA.
Conclusions:
As serum OPG was lower in knee OA and negatively correlated with WOMAC, it seems that detection of OPG in serum but not in saliva may be a probable marker to the diagnosis of knee OA.
Key Messages:
Osteoprotegerin decreases in knee osteoarthritis.
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