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Interferon-Gamma-Producing CD8+ Tissue Resident Memory T Cells Are a Targetable Hallmark of Immune Checkpoint

Sarah C Sasson1, Stephanie M Slevin1, Vincent T F Cheung1

  • 1Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom; National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals National Health Service Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.

Gastroenterology
|June 20, 2021
PubMed
Summary

Immune checkpoint inhibitor (ICI)-colitis is driven by CD8+ tissue-resident memory T cells. These cells, producing interferon-gamma, are a key target for treating ICI-colitis.

Keywords:
Checkpoint ColitisImmunotherapy ColitisTofacitinibUlcerative Colitis

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