A review of emerging technologies enabling improved solid oral dosage form manufacturing and processing

Area of Science:

• Pharmaceutical Sciences
• Materials Science
• Chemical Engineering

Background:

• Tablets are the preferred solid oral dosage form due to patient convenience and stability.
• Significant advancements in tableting technology have occurred over time.

Purpose of the Study:

• To review recent progress in tablet excipients, manufacturing processes, analytical methods, and Quality by Design (QbD) implementation.
• To highlight innovations enhancing tablet performance and production.

Main Methods:

• Review of novel excipients for solubility, disintegration, taste masking, and release modification.
• Exploration of advanced granulation and particle engineering techniques (e.g., hot melt extrusion, nanotechnology).
• Analysis of new tableting technologies (e.g., multilayer, rapidly disintegrating) and non-invasive analytical methods (e.g., laser, tomography).

Main Results:

• Development of multifunctional excipients and advanced granulation methods improve manufacturing efficiency.
• Particle engineering and novel tableting technologies enable customized drug release and robust formulations.
• Non-invasive analytical techniques and process analytical technologies enhance quality control and process understanding.

Conclusions:

• Recent innovations in excipients, manufacturing, and analytics are driving the development of advanced, high-performance tablet dosage forms.
• The integration of Quality by Design principles ensures robust and reliable tablet formulations with improved therapeutic outcomes.