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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples
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Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples

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Cancer stem cells in TNBC.

Zhan Hua1, Jason White2, Jianjun Zhou3

  • 1Department of General Surgery, China-Japan Friendship Hospital, Beijing, 100029, People's Republic of China.

Seminars in Cancer Biology
|June 20, 2021
PubMed
Summary
This summary is machine-generated.

Triple-negative breast cancer (TNBC) is challenging due to its heterogeneity and resistance. Cancer stem cells (CSCs) drive TNBC, and targeting them offers new therapeutic strategies.

Keywords:
Cancer stem cellsHeterogeneitySingle-cell RNA-seqTargeted therapyTriple-negative breast cancer

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genomics

Background:

  • Triple-negative breast cancer (TNBC) lacks targeted therapies due to its heterogeneity.
  • Cancer stem cells (CSCs) contribute to treatment resistance in TNBC.
  • Understanding TNBC's molecular drivers is crucial for developing effective treatments.

Purpose of the Study:

  • To review the role of CSCs in TNBC.
  • To explore therapeutic strategies targeting CSCs in TNBC.
  • To highlight the impact of single-cell technologies in understanding TNBC heterogeneity.

Main Methods:

  • Review of current scientific literature on TNBC and CSCs.
  • Analysis of single-cell technologies like scRNA-seq and proteomics.
  • Discussion of molecular signaling pathways involved in TNBC and CSCs.

Main Results:

  • CSCs are identified as key drivers of TNBC incidence and progression.
  • Single-cell analyses reveal intratumoral heterogeneity and CSC populations.
  • Emerging evidence supports targeting CSCs for TNBC treatment.

Conclusions:

  • CSCs play a critical role in TNBC's aggressive nature and treatment resistance.
  • Targeting CSC-specific molecular signaling presents a promising therapeutic avenue for TNBC.
  • Single-cell technologies are vital for dissecting TNBC complexity and identifying therapeutic targets.