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Updated: Nov 1, 2025

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Tumor angiogenesis: Current challenges and therapeutic opportunities

Fares Hezam Al-Ostoot1, Salma Salah2, Hussien Ahmed Khamees3

  • 1Department of Chemistry, Yuvaraja's College, University of Mysore, Mysuru, India; Department of Biochemistry, Faculty of Education & Science, Al-Baydha University, Baydha, Yemen.

Cancer Treatment and Research Communications
|June 20, 2021
PubMed

Insights

Inhibiting tumor angiogenesis, the process of forming new blood vessels, is crucial for cancer treatment. Combining anti-angiogenic drugs with chemotherapy improves patient outcomes by targeting tumor blood supply.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Angiogenesis is vital for tumor growth, supplying oxygen and nutrients, and facilitating metastasis.
  • Inhibiting angiogenesis can induce tumor hypoxia and necrosis, making it a key cancer treatment strategy.
  • Anti-angiogenic drugs are essential components of multi-modal cancer therapy.

Purpose of the Study:

  • To review the fundamental concepts of tumor angiogenesis.
  • To highlight key angiogenic factors involved in cancer progression.
  • To focus on the therapeutic role of anti-angiogenesis strategies in oncology.

Main Methods:

  • Literature review of scientific publications on tumor angiogenesis and anti-angiogenic therapies.
  • Analysis of the role of angiogenesis in tumor development and dissemination.
  • Examination of anti-angiogenesis strategies in combination with other cancer treatments.

Main Results:

  • Tumor angiogenesis is a critical process supporting tumor growth and spread.
  • Inhibition of angiogenesis can halt tumor growth but is most effective when combined with other therapies.
  • Research continues to improve anti-angiogenic drug efficacy and overcome treatment resistance.

Conclusions:

  • Anti-angiogenesis is a significant strategy in cancer treatment, particularly for solid tumors.
  • Combination therapy, including anti-angiogenic drugs and chemotherapy, is critical for optimal patient outcomes.
  • Further research is needed to enhance anti-angiogenic therapies and address resistance mechanisms.
Keywords:
AngiogenesisAnti-angiogenic drugsBlood vesselHypoxia

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