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Related Experiment Videos

Interrelation between end-systolic pressure-volume and pressure-wall thickness relations.

J D Schipke1, J Alexander, Y Harasawa

  • 1Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205.

The American Journal of Physiology
|September 11, 1988
PubMed
Summary

The end-systolic pressure-thickness relationship (ESPTR) is generally curvilinear but can be approximated as linear within physiological pressures. Contractility changes shift this relationship, offering insights into left ventricular function.

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Area of Science:

  • Cardiovascular Physiology
  • Biomedical Engineering
  • Cardiac Mechanics

Background:

  • The end-systolic pressure-thickness relationship (ESPTR) is a key indicator of left ventricular (LV) performance.
  • Understanding the precise shape and behavior of the ESPTR is crucial for accurately assessing cardiac contractility.
  • Previous models have simplified the ESPTR, necessitating experimental validation across various physiological conditions.

Purpose of the Study:

  • To predict the shape of the ESPTR using a thick-walled sphere model of the left ventricle.
  • To experimentally measure and validate the ESPTR across a wide range of volumes in isolated canine hearts.
  • To investigate the influence of contractile state on the ESPTR under different pressure conditions.

Main Methods:

Related Experiment Videos

  • Computational modeling of the left ventricle as a thick-walled sphere to predict ESPTR.
  • In vitro experiments using isolated, blood-perfused canine hearts to measure ESPTR.
  • Systematic variation of cardiac volume and assessment of end-systolic pressure and wall thickness.
  • Analysis of the ESPTR's linearity/curvilinearity and shifts in response to altered contractile state.

    • Main Results:

    • Both simulations and experiments confirmed a curvilinear ESPTR.
    • Within the physiological systolic pressure range (80-150 mmHg), the ESPTR was well-approximated by a straight line.
    • Changes in left ventricular contractility resulted in parallel shifts of the ESPTR in the physiological pressure range.
    • In lower pressure ranges (<80 mmHg), contractility changes were associated with alterations in the slope of the ESPTR.

    Conclusions:

    • The ESPTR exhibits a curvilinear shape, but a linear approximation is valid within physiological systolic pressures.
    • While ESPTR has limitations for assessing left ventricular contractility, it can be useful if these limitations are understood.
    • Contractility assessment using ESPTR requires careful consideration of the prevailing pressure ranges and potential for parallel shifts versus slope changes.