Muscle activation pattern during two-legged hopping in children with and without down syndrome

This study aimed to characterize muscle activation and its variability during two-legged hopping in children with and without Down syndrome (DS). Seventeen typically developing (TD) children and 15 children with DS were recruited. As only 6 children with DS (4F/2M, 9.95 (1.71) years) completed the test, we used a 2(TD):1(DS) ratio to age- and sex-match 12 TD children. Subjects first hopped at a self-selected free frequency and then three metronome-cued conditions: slow, preferred, and moderate (80%, 100%, and 120% of free frequency, respectively). Across conditions, children with DS exhibited greater pre-activation before landing and greater shape and timing variability in gastrocnemius, vastus lateralis, and biceps femoris than TD children. However, this compensatory strategy limited their ability to change movement speed.