Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

13.3K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
13.3K
Abnormal Proliferation02:23

Abnormal Proliferation

4.8K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.8K
The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

7.2K
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
7.2K
Mismatch Repair01:20

Mismatch Repair

5.6K
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
5.6K
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

5.3K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
5.3K
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

12.3K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
12.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

M.globosa promotes lung cancer progression and M2 macrophage polarization through oxidative phosphorylation.

NPJ precision oncology·2026
Same author

Assessment of the mechanical performance of a novel CT-linac treatment couch.

Frontiers in oncology·2026
Same author

Gut microbiota-associated nutritional-immune status predicts prognosis in postoperative NSCLC patients.

Gut microbes·2026
Same author

High-risk EBV promotes immune evasion in nasopharyngeal carcinoma by upregulating HLA-DP via the encoded BALF2-HR variant.

Nature communications·2026
Same author

The cGAS-STING pathway in cancer: friend or foe.

Cell death & disease·2026
Same author

Pseudouridine synthases upregulate 5'-tRF-Lys to inhibit YPEL3 and drive malignant progression in nasopharyngeal carcinoma.

Cellular & molecular biology letters·2026
Same journal

[Formative years of a distinguished medical scholar at Xiangya: Commemorating the 120th anniversary of Professor Wu Zhizhong<b>'</b>s birth].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences·2026
Same journal

[Misdiagnosis of a giant hepatic perivascular epithelioid cell tumor: A case report].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences·2026
Same journal

Janus kinase inhibitors enhance the efficacy of dupilumab in refractory atopic dermatitis.

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences·2026
Same journal

[Comparative efficacy of island latissimus dorsi myocutaneous flap versus lower trapezius myocutaneous flap for repair of posterior neck skin and soft tissue defects].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences·2026
Same journal

[Mechanisms of RNA-binding protein phase separation in steroid-associated necrosis of the femoral head].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences·2026
Same journal

[Breath metabolomic characteristics of schizophrenia and their potential for auxiliary diagnosis].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences·2026
See all related articles

Related Experiment Video

Updated: Nov 1, 2025

Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells
11:06

Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells

Published on: February 24, 2014

13.2K

Genome instability and lymphoma.

Pengfei Cao1,2, Guiyuan Li3, Juanjuan Xiang4

  • 1Department of Hematology, Xiangya Hospital, Central South University, Changsha 410008. caopengfei66@163.com.

Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences
|June 21, 2021
PubMed
Summary
This summary is machine-generated.

Genome instability, including microsatellite and chromosomal instability, is crucial in lymphoma development and prognosis. Studying unstable genes offers insights into lymphoma mechanisms and precision medicine.

Keywords:
chromosomal instabilitygenome instabilitylymphomamicrosatellite instability

More Related Videos

Rapid Analysis of Chromosome Aberrations in Mouse B Lymphocytes by PNA-FISH
07:54

Rapid Analysis of Chromosome Aberrations in Mouse B Lymphocytes by PNA-FISH

Published on: August 19, 2014

17.3K
Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice
17:59

Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice

Published on: April 3, 2011

12.5K

Related Experiment Videos

Last Updated: Nov 1, 2025

Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells
11:06

Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells

Published on: February 24, 2014

13.2K
Rapid Analysis of Chromosome Aberrations in Mouse B Lymphocytes by PNA-FISH
07:54

Rapid Analysis of Chromosome Aberrations in Mouse B Lymphocytes by PNA-FISH

Published on: August 19, 2014

17.3K
Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice
17:59

Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice

Published on: April 3, 2011

12.5K

Area of Science:

  • Hematologic Oncology
  • Cancer Genomics

Background:

  • Lymphoma is a prevalent hematologic malignancy.
  • Genome instability is a key factor in lymphoma pathogenesis, diagnosis, and prognosis.
  • Two main types of genome instability exist: microsatellite instability (MSI/MIN) and chromosomal instability.

Purpose of the Study:

  • To identify unstable genes associated with lymphoma.
  • To explore the mechanisms underlying lymphoma development.
  • To provide a molecular basis for precision medicine in lymphoma research.

Main Methods:

  • Gene association studies in lymphoma.
  • Analysis of microsatellite instability (MSI/MIN).
  • Assessment of chromosomal instability.

Main Results:

  • Identification of specific unstable genes implicated in lymphoma.
  • Elucidation of molecular mechanisms driving lymphoma progression.
  • Establishment of genome instability as a significant biomarker.

Conclusions:

  • Genome instability is fundamental to lymphoma.
  • Understanding unstable genes aids in lymphoma diagnosis and prognosis.
  • This research supports advancements in lymphoma precision medicine.