Related Experiment Video
Updated: Nov 1, 2025
09:07
Using Zebrafish Models of Human Influenza A Virus Infections to Screen Antiviral Drugs and Characterize Host Immune Cell Responses
Published on: January 20, 2017
10.1K
COVID-19 and Ivermectin: Potential threats associated with human use
Tean Zaheer1, Kaushik Pal2, Rao Zahid Abbas1
1Chemotherapy Laboratory, Department of Parasitology, University of Agriculture, Faisalabad- 38040, Pakistan.
Journal of Molecular Structure
|June 21, 2021
Summary
Ivermectin shows promise against COVID-19 in early studies, but more clinical trials are needed to confirm efficacy and safety. Further research into ivermectin (IVM) for SARS-CoV-2 treatment is essential.
Area of Science:
- Virology and Drug Discovery
- Infectious Diseases Research
Background:
- Drug repurposing is a key strategy for combating emerging viral threats like COVID-19.
- Ivermectin (IVM), known for its broad-spectrum antipathogenic activity, has emerged as a popular candidate.
- While in vitro studies show promise, robust clinical evidence for IVM against SARS-CoV-2 is still required.
Purpose of the Study:
- To review the current evidence and potential of ivermectin as a treatment and preventative measure for COVID-19.
- To highlight the need for further clinical trials and analysis of projected IVM use.
- To discuss potential toxicity and dosage considerations for ivermectin in the context of SARS-CoV-2.
Main Methods:
- Literature review of existing studies on ivermectin's efficacy against viruses.
- Analysis of in vitro data and ongoing clinical trials for ivermectin in COVID-19.
- Examination of ivermectin's application in veterinary medicine for relevant insights.
Main Results:
- Ivermectin demonstrates potential in preliminary in vitro investigations against SARS-CoV-2.
- Clinical trial data supporting ivermectin's efficacy for COVID-19 treatment and prevention remains limited.
- Concerns regarding potential toxicity and optimal dosing require thorough investigation.
Conclusions:
- Ivermectin warrants further rigorous clinical investigation for its role in managing COVID-19.
- Lessons from veterinary use and ongoing trials can inform future strategies for ivermectin.
- Careful evaluation of safety and efficacy is crucial before widespread adoption of ivermectin for COVID-19.
More Related Videos
04:28Utilizing an Orally Dissolving Strip for Pharmacological and Toxicological Studies: A Simple and Humane Alternative to Oral Gavage for Animals
Published on: March 23, 2016
12.9K
05:08Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
Published on: July 8, 2025
522
Related Concept Videos
01:26Pharmacokinetics: Drug–Food and Drug–Viral Interactions
44
A drug interaction occurs when the concurrent use of another drug, food, or an external substance alters the pharmacological activity of a drug. This interaction can modify the action of the original drug, affecting its effectiveness and safety.Drug–food interactions are significant as they impact drug absorption, metabolism, and excretion. For example, grapefruit juice is a well-known disruptor of drug metabolism. It inhibits the cytochrome P450 3A4 enzyme, crucial for the metabolism of...
44
01:26Factors Affecting the Risk of Infection
13.0K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.0K
01:25Pharmacokinetics: Drug–Drug Interactions
61
Drug interactions occur when the pharmacological effect of one drug is altered by another substance, either enhancing or diminishing its activity. The drug whose activity is altered is known as the object drug, and the substance causing the alteration is called the agent drug or the precipitant. The net effects of these interactions are mostly undesirable, leading to decreased effectiveness or increased adverse effects. In rare cases, interactions can be beneficial, such as the enhanced...
61
01:36Types of Toxins
2.7K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
2.7K
01:26Heart Failure Drugs: Inotropic Agents
885
Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
885
01:20Infection
9.5K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
9.5K