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An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
Published on: March 30, 2018
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Fatal Systemic Vasculitis Associated with Chronic Active Epstein-Barr Virus Infection
Oumama Jamal1, Nawal Sahel1, Rachida Saouab2
1Department of Internal Medicine A, Mohammed V Military Instruction Hospital, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University, Rabat, Morocco.
Missouri Medicine
|June 21, 2021
Summary
Chronic active Epstein-Barr virus infection can cause fatal systemic vasculitis and aneurysms. This case highlights the severe cardiovascular complications and poor prognosis, even with treatment.
Area of Science:
- Immunology
- Cardiology
- Infectious Diseases
Background:
- Chronic active Epstein-Barr virus (CAEBV) infection is a rare and often fatal condition.
- Cardiovascular complications in CAEBV significantly worsen patient prognosis.
Purpose of the Study:
- To describe the clinical course of an adult patient with EBV-associated systemic vasculitis.
- To highlight the development and impact of multi-systemic aneurysmal disease in this context.
Main Methods:
- Case report detailing clinical presentation and progression.
- Vascular imaging (angiography) to identify aneurysms.
- Immunophenotyping of peripheral blood lymphocytes.
Main Results:
- The patient presented with EBV-associated systemic vasculitis and widespread aneurysms (coronary, abdominal, cerebral, vertebral arteries).
- Immunophenotyping revealed an increased population of double-negative T cells.
- The patient showed no response to multiple immunosuppressive therapies.
Conclusions:
- EBV-associated vasculitis can lead to severe, multi-systemic aneurysmal disease.
- The presence of double-negative T cells may be a relevant finding.
- The condition carries a poor prognosis, as exemplified by the fatal outcome due to cerebral aneurysm rupture.
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