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Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

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Bereitschaftspotential in Multiple System Atrophy.

Yi-Chien Yang^1,2, Fang-Tzu Chang^1,2, Jui-Cheng Chen^1,2,3,4

¹Department of Neurology, China Medical University Hospital, Taichung, Taiwan.

Frontiers in Neurology

|June 21, 2021

Summary

This summary is machine-generated.

Patients with multiple system atrophy (MSA) show impaired motor cortical preparation and activation, particularly evident in late Bereitschaftspotential (BP) amplitudes. This dysfunction, measurable via late BP, highlights motor control circuitry issues in MSA subtypes.

Keywords:

Bereitschaftspotential movement-related cortical potential multiple system atrophy neurodegenerative disorder parkinsonism

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Area of Science:

Neuroscience
Neurology
Clinical Electrophysiology

Background:

Multiple system atrophy (MSA) is a neurodegenerative disorder with subtypes MSA-P and MSA-C.
The precise involvement of motor control circuitry in MSA subtypes remains unclear.
Bereitschaftspotential (BP) offers a clinical measure of electroencephalographic activity preceding volitional movements.

Purpose of the Study:

To investigate motor cortical preparation and activation in patients with MSA-P and MSA-C.
To compare BP recordings between MSA subtypes and healthy controls.
To assess the utility of BP in evaluating motor control dysfunction in MSA.

Main Methods:

Recorded BP during self-paced wrist extension in 8 MSA-P patients, 8 MSA-C patients, and 8 healthy controls.
Time-locked electroencephalographic epochs to electromyography onset.
Compared mean amplitudes of early (1500-500 ms) and late (500-0 ms) BP across groups.

Main Results:

Early BP amplitude did not significantly differ between groups.
Late BP amplitude was significantly reduced in the parietal area of both MSA groups compared to controls.
The MSA-C group showed a further significant reduction in late BP at the central parietal area.

Conclusions:

Patients with MSA exhibit motor cortical dysfunction in voluntary movement preparation and activation.
Late BP is a practical clinical tool for evaluating this dysfunction.
Reduced late BP suggests involvement of the cerebello-dentato-thalamo-cortical pathway in MSA.