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Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells
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Mesenchymal Stem Cell-Derived Extracellular Vesicles: A Potential Therapeutic Strategy for Acute Kidney Injury

Jia-Kun Li1, Cheng Yang2, Ying Su1

  • 1Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.

Frontiers in Immunology
|June 21, 2021
PubMed

Insights

Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) show promise for treating acute kidney injury (AKI). MSC-EVs offer advantages over MSCs, including lower immunogenicity and easier storage, for potential AKI therapies.

Area of Science:

  • Nephrology
  • Regenerative Medicine
  • Biotechnology

Background:

  • Acute kidney injury (AKI) affects 10-15% of hospitalizations and 50% of ICU patients.
  • Severe AKI can progress to chronic kidney disease or end-stage renal disease.
  • Current AKI treatments are primarily supportive, necessitating more effective therapies.

Purpose of the Study:

  • To review the therapeutic mechanisms of Mesenchymal Stem Cells (MSCs) and MSC-derived Extracellular Vesicles (MSC-EVs) in AKI.
  • To explore recent advancements in enhancing MSC-EV efficacy for AKI treatment.
  • To analyze the potential and limitations of EVs for AKI therapy.

Main Methods:

  • Literature review of MSCs and MSC-EVs in AKI.
  • Analysis of therapeutic mechanisms and recent research findings.
  • Evaluation of the potential and limitations of EV-based therapies.

Main Results:

  • MSCs are promising for cellular therapy due to ease of harvesting and low immunogenicity.
  • Therapeutic effects of MSCs are mainly mediated by MSC-EVs.
  • MSC-EVs offer advantages over MSCs, including lower immunogenicity, easier storage, and no tumorigenesis.

Conclusions:

  • MSC-EVs represent a promising therapeutic strategy for AKI.
  • Further research and clinical trials are needed to optimize MSC-EV efficacy and application.
  • MSC-EVs have significant potential for the clinical treatment of AKI.

Keywords:
acute kidney injurycytokineextracellular vesiclemesenchymal stem celltubular epithelial cell

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