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Updated: Nov 1, 2025
Roux-en-Y Gastric Bypass Operation in Rats
Published on: June 11, 2012
Effect of left or right gastric artery interventional embolization on obesity and ghrelin/leptin expression in pigs
Hui Liu1, Xiangying Li2, Rihui Chen1
1Department of Interventional Radiology, Central South University, Xiangya School of Medicine Affiliated Haikou Hospital Haikou, Hainan Province, China.
Objective:
To investigate the effect of left or right gastric artery interventional embolization on obesity and ghrelin/leptin expression in pigs.
Methods:
Thirty-two female Wuzhishan pigs aged 3-4 months were randomly divided into four groups, with eight pigs in each group: obesity + left gastric artery embolization group, obesity + right gastric artery embolization group, obesity + sham surgery group and healthy control group. The body weight and serum levels of ghrelin, leptin, interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) before the operation, one month and three months after the operation, and the gastric pathology three months after the operation were compared.
Results:
The preoperative body weight, ghrelin level, leptin level, IL-6 level and TNF-α level of the obesity + sham surgery group, obesity + left gastric artery embolization group and obesity + right gastric artery embolization group were higher than those of the healthy control group (all P<0.05). One month after the operation, the body weight, ghrelin level, leptin level, IL-6 level and TNF-α level of the obesity + sham surgery group, obesity + left gastric artery embolization group and obesity + right gastric artery embolization group were higher than those of the healthy control group. The body weight, ghrelin level, IL-6 level and TNF-α level of the obesity + sham surgery group were higher than those of the obesity + left artery embolization group and obesity + right gastric artery embolization group (all P<0.05). Three months after the operation, the body weight, ghrelin level, leptin level, IL-6 level and TNF-α level of the obesity + sham surgery group were higher than those of the obesity + left artery embolization group, obesity + right artery embolization group and the healthy control group (all P<0.05).
Conclusion:
Left or right gastric artery interventional embolization in pigs can effectively reduce body weight, which may be related to the reduced secretion of ghrelin, leptin and inflammatory factors. However, the clinical application and safety of left or right gastric artery embolization still need further study.
