Related Experiment Video
Updated: Nov 1, 2025

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
Published on: January 20, 2023
Minor Head Injury Might Cause Treatable Dementia Due to Severe Hyponatremia
1Dr. Nagamine is with the Sunlight Brain Research Center in Hofu, Yamaguchi, Japan.
Abstract:
OBJECTIVE: There are several conditions of treatable dementia. Among these, hyponatremia can cause transitory modification of cognitive functions. DESIGN: We treated a patient with cognitive decline after minor head injury who developed severe hyponatremia due to central salt wasting syndrome (CSWS). RESULTs: Head injuries can interfere with the normal neuroendocrine function of the hypothalamus and pituitary system, resulting in CSWS. A short-term infusion of isotonic saline solution might be useful in identifying CSWS. CONCLUSION: Follow-up laboratory tests, including ones that test serum sodium leves, are recommended even in patients with minor head injury to diagnose potentially reversible conditions similar to dementia.
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