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Quantitative parameters of body composition and theophylline disposition
T L Joliat1, F E Leickly, D R Ownby
1Henry Ford Hospital, Detroit, Michigan.
Annals of Allergy
|September 1, 1988
Summary
Body composition analysis using the BA-101 accurately measures body fat and lean mass. However, while body composition correlated with theophylline distribution, it did not improve starter dose prediction in healthy males.
Area of Science:
- Pharmacokinetics
- Body Composition Analysis
- Clinical Pharmacology
Background:
- Accurate dosing of medications like theophylline is crucial for therapeutic efficacy.
- Body composition significantly influences drug distribution and elimination.
- The BA-101 Body Composition Analyzer provides detailed body composition metrics.
Purpose of the Study:
- To investigate the relationship between body composition parameters and the volume of distribution of theophylline.
- To determine if body composition analysis can improve the prediction of theophylline starter dose.
Main Methods:
- Utilized the BA-101 Body Composition Analyzer to measure percent fat, total body water, and lean body weight.
- Assessed 16 healthy adult males.
- Measured the volume of distribution of theophylline in the study subjects.
Main Results:
- A strong positive correlation was observed between the lean to fat ratio and theophylline volume of distribution (r = .767).
- A strong negative correlation was found between percent body fat and theophylline volume of distribution (r = -0.79).
- Body composition data did not enhance the accuracy of predicting theophylline starter dose.
Conclusions:
- Body composition, particularly lean/fat ratio and percent fat, is significantly associated with theophylline's volume of distribution.
- Current body composition analysis methods do not provide a more accurate prediction for theophylline starter dosing.