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The Emerging Roles of circFOXO3 in Cancer

Dean Rao1,2, Chengpeng Yu1,2, Jiaqi Sheng1,2

  • 1Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Frontiers in Cell and Developmental Biology
|June 21, 2021
PubMed

Insights

Circular RNAs (circRNAs) are stable molecules involved in cancer. CircRNA Forkhead box O3 (circFOXO3) shows abnormal expression in various cancers, acting as a molecular sponge, but its full functions require further research.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Circular RNAs (circRNAs) are non-coding RNAs formed by mRNA reverse splicing.
  • Their unique structure confers stability, making them resistant to degradation.
  • CircRNAs are tissue-specific and play roles in various diseases, particularly cancer.

Purpose of the Study:

  • To review the roles and molecular mechanisms of circRNA Forkhead box O3 (circFOXO3) in cancer.
  • To summarize the involvement of circFOXO3 and its target genes in diverse cancer types.
  • To highlight the need for further research into the multifaceted functions of circFOXO3.

Main Methods:

  • Literature review of studies on circFOXO3 in various cancers.
  • Analysis of circFOXO3's role as a molecular sponge.
  • Discussion of circFOXO3's impact on cancer proliferation, invasion, and prognosis.

Main Results:

  • CircFOXO3 is abnormally expressed in multiple cancers, including prostate, liver, brain, bladder, and breast cancers.
  • CircFOXO3 functions as a molecular sponge, influencing cancer development.
  • The precise roles and mechanisms of circFOXO3 in cancer are not fully elucidated.

Conclusions:

  • CircFOXO3 is implicated in the progression of various cancers.
  • Understanding circFOXO3's molecular mechanisms can enhance cancer research.
  • Further investigation is crucial to fully comprehend circFOXO3's diverse functions in oncology.
Keywords:
biomarkercancercircFOXO3circular RNAmicroRNA sponge

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