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Updated: Nov 1, 2025
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Bilateral vision loss as the initial presentation for central nervous system involvement of mantle cell lymphoma: A
1Department of Ophthalmology, University of California San Francisco, San Francisco, CA, USA.
Purpose:
Mantle cell lymphoma is a rare aggressive subtype of non-Hodgkins B cell lymphoma. It typically presents with asymptomatic monoclonal lymphocytosis, lymphadenopathy or bulky extranodal disease. Mantle cell lymphoma rarely affects the central nervous system. We present two cases in which vision loss was the initial symptom of central nervous system involvement by the malignancy.
Observations:
Both patients initially received high dose intravenous steroids with notable improvement in their vision.
Conclusions And Importance:
Early detection and management of optic nerve infiltration by mantle cell lymphoma is essential as it improves visual outcomes and enables prompt management of the patient's systemic disease.
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