Related Experiment Video
Updated: Nov 1, 2025

Antigen-Capture Enzyme-Linked Immunosorbent Assay for Specific Detection of Mycoplasma pneumoniae
Published on: February 24, 2023
Mycoplasma pneumoniae co-infection with SARS-CoV-2: A case report
Rama Chaudhry1, K Sreenath1, E V Vinayaraj1
1Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.
Abstract:
We report co-infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Mycoplasma pneumoniae in a patient with pneumonia in India. Atypical bacterial pathogens causing community-acquired pneumonia may share similar clinical presentations and radiographic features with SARS-CoV-2 making a thorough differential diagnosis essential. The co-infection of SARS-CoV-2 and M. pneumoniae is infrequently reported in the literature. Broader testing for common respiratory pathogens should be performed in severe COVID-19 cases to rule out other concurrent infections. Early identification of co-existing respiratory pathogens could provide pathogen-directed therapy, and can save patient lives during the ongoing COVID-19 outbreak.
Insights
Severe COVID-19 cases can present with co-infection of SARS-CoV-2 and Mycoplasma pneumoniae. Broader pathogen testing is crucial for accurate diagnosis and timely treatment of severe respiratory infections.
Area of Science:
- Infectious Diseases
- Microbiology
- Pulmonology
Background:
- Community-acquired pneumonia (CAP) diagnosis can be challenging due to overlapping symptoms with viral infections.
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can present with atypical bacterial co-infections.
- Mycoplasma pneumoniae is a common cause of atypical pneumonia.
Observation:
- A case of co-infection with SARS-CoV-2 and Mycoplasma pneumoniae was identified in a patient with pneumonia in India.
- Clinical and radiographic features of SARS-CoV-2 and M. pneumoniae can be similar, complicating differential diagnosis.
Findings:
- Co-infection of SARS-CoV-2 and M. pneumoniae is infrequently reported.
- This case highlights the importance of considering bacterial co-infections in severe COVID-19.
Implications:
- Comprehensive testing for common respiratory pathogens is recommended in severe COVID-19 cases.
- Early identification of co-existing pathogens enables pathogen-directed therapy.
- Timely diagnosis and treatment of co-infections can improve patient outcomes and save lives during the COVID-19 pandemic.
More Related Videos
12:21A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
Published on: September 28, 2022
10:47Using Bioluminescent Imaging to Investigate Synergism Between Streptococcus pneumoniae and Influenza A Virus in Infant Mice
Published on: April 14, 2011
Related Concept Videos
Pneumonia II: Pathophysiology
Pneumonia III: Complications and Assessment
Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Pneumonia V: Nursing management and Prevention
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
Pneumonia IV: Management
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Pulmonary Tuberculosis II
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...