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Encapsulation and controlled release of an antimalarial drug using surface functionalized mesoporous silica
Haruka Hirayama1, Saliu Alao Amolegbe2, Md Saidul Islam3
1Department of Chemistry, Graduate School of Science and Technology, Kumamoto University, 2-39-1 Kurokami, Chuo-ku, Kumamoto 860-8555, Japan. hayami@kumamoto-u.ac.jp.
Journal of Materials Chemistry. B
|June 21, 2021
Abstract:
Herein, we report the encapsulation and release of antimalarial drug quinine (QN) using three nanocarriers, including MCM-41 (1), and its 3-aminopropyl silane (aMCM-41 (2)) and 3-phenylpropyl silane (pMCM-41 (3)) surface functionalized derivatives. The pH and thermal optimization effects on QN adsorption and release from 1, 2 and 3 were investigated.
