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Burnt bridge ratchet motor force scales linearly with polyvalency: a computational study
1Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA and Michigan Society of Fellows, University of Michigan, Ann Arbor, Michigan 48109, USA. atblanchard@ymail.com.
Abstract:
Nano- and micro-scale burnt bridge ratchet motors, which translocate via "guide" molecules that bind to and degrade a field of "fuel" molecules, have recently emerged in several biological and engineering contexts. The capacity of these motors to generate mechanical forces remains an open question. Here, chemomechanical modeling suggests that BBR force scales linearly with the steady-state number of guide-fuel bonds.
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