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Impact of YTHDF1 gene polymorphisms on Wilms tumor susceptibility: A five-center case-control study

Yanfei Liu1, Huiran Lin2, Rui-Xi Hua3

  • 1Department of Pathology, Xi'an Children's Hospital, The Affiliated Children's Hospital of Xi'an Jiaotong University, Xi'an, China.

Journal of Clinical Laboratory Analysis
|June 21, 2021
PubMed

Insights

Genetic variants in the YTHDF1 gene were investigated for their role in childhood Wilms tumor risk. While overall risk was not associated, specific YTHDF1 polymorphisms showed age-dependent associations in Wilms tumor development.

Area of Science:

  • Genetics
  • Pediatric Oncology
  • Molecular Biology

Background:

  • Wilms tumor is the most common kidney cancer in children.
  • YTHDF1 gene involvement is known in various cancers.
  • The impact of YTHDF1 genetic variants on Wilms tumor risk remains unclear.

Purpose of the Study:

  • To investigate the association between YTHDF1 gene single nucleotide polymorphisms (SNPs) and Wilms tumor risk.
  • To analyze the influence of specific YTHDF1 SNPs (rs6011668 and rs6090311) on Wilms tumor susceptibility.

Main Methods:

  • A hospital-based case-control study was conducted with 408 Wilms tumor cases and 1198 controls from China.
  • Unconditional logistic regression analysis was used to assess the risk associated with YTHDF1 SNPs.
  • Odds ratios (OR) and 95% confidence intervals (CI) were calculated for YTHDF1 variants rs6011668 and rs6090311.

Main Results:

  • Neither rs6011668 nor rs6090311 individually showed a significant association with overall Wilms tumor risk.
  • A negative association was observed for combined protective genotypes.
  • Stratification analysis indicated that the rs6011668 CT/TT genotype was linked to increased risk in younger children (≤18 months) but decreased risk in older children (>18 months).

Conclusions:

  • YTHDF1 gene polymorphisms may play a role in Wilms tumor risk.
  • Age-specific effects of YTHDF1 variants on Wilms tumor susceptibility were identified.
Abstract

Keywords:
YTHDF1Wilms tumorcase-control studypolymorphismrisk

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