Glioma Associated Microglia/Macrophages Distribution is Conserved in Glioblastoma Regrowth: A Morphometric Study

We compared the morphological aspect of glioblastoma-associated microglia/macrophages cells in 15 paired recurrent glioblastomas to check the ability of glioblastoma to recreate its microenvironment. The absolute number of GAMs is lower in normal tissue (21/mm²) than in the isolated tumor cells area (100-112/mm²) than in the solid tumor area (212-220/mm²) (p < 0.01). The morphology of GAMs remained the same in each tumor area with a reduced covered area by cell processes (196 to 216/mm²) than in normal tissue (708/mm²) (p < 0.01). In paired tumors, GAMs morphology remained the same in successive resections and was not modified by the treatments.