Effect of a Multidomain Lifestyle Intervention on Estimated Dementia Risk
Alina Solomon1,2, Ron Handels3,4,5, Anders Wimo5
1Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland.
Journal of Alzheimer'S Disease : JAD
|June 21, 2021
Summary
A multidomain lifestyle intervention significantly reduced dementia risk in older adults by 6.5% over two years. This finding highlights the potential of lifestyle changes for cognitive health prevention.
Area of Science:
- Gerontology
- Neurology
- Preventive Medicine
Background:
- The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) evaluated a multidomain lifestyle intervention.
- This post-hoc analysis focused on the intervention's effect on dementia risk using the CAIDE risk score.
Discussion:
- The intervention group showed a statistically significant reduction in the CAIDE dementia risk score compared to the control group.
- The observed risk reduction suggests a tangible benefit of the intervention in mitigating dementia risk.
Key Insights:
- A 2-year multidomain lifestyle intervention led to a mean difference of -0.16 in the CAIDE risk score (p=0.013).
- This translates to a relative dementia risk reduction of approximately 6.04-6.50%.
Outlook:
- The FINGER intervention demonstrates significant potential for dementia risk reduction in at-risk older populations.
- Further research can explore long-term effects and broader implementation strategies for lifestyle-based cognitive prevention.
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