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Chronic unilateral optic neuropathy: a magnetic resonance study
D Eidelberg1, M R Newton, G Johnson
1NMR Research Group, National Hospital, London, England 63110.
Annals of Neurology
|July 1, 1988
Summary
Magnetic resonance imaging (MRI) effectively identified causes of chronic unilateral optic neuropathy (CUON) in 20 patients. MRI distinguished between extrinsic compression, intrinsic tumors, and nerve signal changes, aiding diagnosis.
Area of Science:
- Ophthalmology
- Neurology
- Radiology
Background:
- Chronic unilateral optic neuropathy (CUON) presents as progressive visual failure.
- Accurate diagnosis is crucial for effective management of optic nerve dysfunction.
Purpose of the Study:
- To evaluate the utility of MRI, specifically short TI inversion recovery (STIR) sequences, in assessing patients with CUON.
- To categorize CUON based on MRI findings and compare MRI with computed tomography (CT).
Main Methods:
- Clinical, electrophysiological, and MRI assessments were performed on 20 CUON patients.
- MRI with STIR sequences was used to visualize the optic nerve and surrounding tissues.
- Findings were correlated with clinical presentation and, where applicable, CT scans.
Main Results:
- MRI identified three groups: extrinsic mass compression (8/20), intrinsic optic nerve tumors (5/20), and no mass with altered nerve signal (7/20).
- STIR sequences were comparable to CT for mass detection and superior for delineating nerve distortion.
- Altered nerve signals on STIR and periventricular lesions on T2-weighted MRI were observed in some patients.
Conclusions:
- MRI, particularly STIR sequences, is a valuable tool for diagnosing CUON.
- It aids in differentiating causes of optic nerve dysfunction and complements clinical and electrophysiological evaluations.