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Neurological basis of respiratory complications in achondroplasia
F W Nelson1, J T Hecht, W A Horton
1Department of Neurology, University of Texas Health Science Center, Houston 77225.
Annals of Neurology
|July 1, 1988
Abstract:
Evaluation of 32 individuals with achondroplasia revealed that 28% had a history of apnea and 22% had respiratory abnormalities on polysomnography. In those patients requiring posterior fossa decompressive surgery, improvement was noted in follow-up polysomnograms. Multimodality studies suggested that brainstem compression was common in achondroplasia and could account in part for the abnormal respiratory function in this disorder, including obstructive apnea, central apnea, and hypoxemia.