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Activity of amikacin against Mycobacterium avium complex under simulated in vivo conditions
P R Gangadharam1, L Kesavalu, P N Rao
1National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206.
Antimicrobial Agents and Chemotherapy
|June 1, 1988
Abstract:
We studied the activity of amikacin against Mycobacterium avium complex strain 101 by using continuous-level, changing concentrations which simulated levels in serum in a patient, and pulsed exposures. Amikacin at a concentration of 5 or 15 micrograms/ml showed rapid bactericidal action following constant exposure of the organisms. With the in vitro model, using a peak concentration of 10 or 20 micrograms/ml, complete sterilization was obtained by day 7. In pulsed-exposure studies, a minimum period of contact of 72 or 96 h at a concentration of 10 micrograms/ml was needed for complete sterilization.