Nanocapsules with excellent biocompatibility and stability in protein solutions

Silica nanocapsules (SiO₂NCs) are usually prepared with cationic surfactants that are not cytocompatible. Dialysis can be used to remove surfactants but leads to instability of the SiO₂NCs when they are in the presence of proteins or biological media. Herein, SiO₂NCs stabilized with a reactive surfactant are synthesized to prevent leaching upon dialysis. The SiO₂NCs show superior stability and biocompatibility compared with SiO₂NCs prepared with conventional surfactants. The SiO₂NCs can be used in self-healing materials, smart agriculture and biomedical applications.