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Clinical Profile and Risk Factors for Severe Disease in 402 Children Hospitalized with SARS-CoV-2 from India:

Kana Ram Jat1, Jhuma Sankar1, Rashmi Ranjan Das2

  • 1Department of Pediatrics, All India Institute of Medical Sciences, New Delhi 110029, India.

Journal of Tropical Pediatrics
|June 21, 2021
PubMed

Insights

This study describes the clinical features and risk factors for severe coronavirus disease (COVID-19) in Indian children. High urea and low total serum protein were identified as novel risk factors for severe COVID-19 in pediatric patients.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Limited multicentric studies on pediatric COVID-19 exist from developing nations.
  • Understanding the clinical profile and risk factors in Indian children is crucial.

Purpose of the Study:

  • To describe the clinical characteristics of children hospitalized with COVID-19 in India.
  • To identify risk factors associated with severe disease in this pediatric population.

Main Methods:

  • Retrospective multicentric study involving 402 children in India.
  • Data collected included demographics, clinical features, laboratory results, and outcomes.
  • Analysis focused on identifying factors linked to moderate to severe COVID-19.

Main Results:

  • Fever was the most common symptom; 44% had comorbidities.
  • The majority were asymptomatic or mildly symptomatic; 9.7% had moderate-severe disease, and 3.2% died.
  • Laboratory abnormalities included lymphopenia, thrombocytopenia, transaminitis, and elevated inflammatory markers; high urea and low total serum protein were associated with severe disease.

Conclusions:

  • Fever is the most common symptom in pediatric COVID-19 in India.
  • Novel risk factors for severe disease, including high urea and low total serum protein, were identified.
  • Most children experienced mild or no symptoms, but specific factors indicate a risk for severe outcomes.
Abstract

Keywords:
COVID-19IL-6SRAS-CoV-2childrenferritin

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