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GSK3 Inhibitor-Induced Dentinogenesis Using a Hydrogel.

A Alaohali1,2, C Salzlechner1, L K Zaugg1,3

  • 1Centre for Craniofacial and Regenerative Biology, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK.

Journal of Dental Research
|June 21, 2021
PubMed
Summary
This summary is machine-generated.

A new drug, NP928, delivered via a hyaluronic acid hydrogel, effectively stimulates reparative dentine formation in teeth. This innovative approach offers a promising clinical treatment for exposed pulp lesions.

Keywords:
Wnt signalingdental pulpdentinemineralizationstem cellstissue engineering

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Area of Science:

  • Biomaterials Science
  • Dental Regenerative Medicine
  • Pharmacology

Background:

  • Glycogen synthase kinase 3 (GSK3) inhibitors promote reparative dentine formation.
  • Previous delivery methods using collagen sponges required in-theater preparation.
  • A novel thiadiazolidinone (TDZD) drug, NP928, shows promise for dental pulp regeneration.

Purpose of the Study:

  • To develop a clinically viable method for delivering NP928 to exposed pulp lesions.
  • To create a novel biodegradable hydrogel for syringe-based delivery of NP928.
  • To evaluate the efficacy of NP928-loaded hydrogel in stimulating reparative dentine formation.

Main Methods:

  • Synthesis of NP928, a water-soluble TDZD-family drug.
  • Incorporation of NP928 into a hyaluronic acid-based hydrogel.
  • In situ gelation of the hydrogel using dental blue light.
  • Assessment of NP928 release and its effect on Wnt/β-catenin activity and dentine formation in pulp stem cells.

Main Results:

  • NP928 incorporated into hyaluronic acid hydrogel was successfully delivered by syringe.
  • The hydrogel formulation facilitated in situ gelation for improved handling.
  • NP928 released from the hydrogel upregulated Wnt/β-catenin signaling in pulp stem cells.
  • The drug-hydrogel combination significantly fostered reparative dentine formation compared to collagen sponges.

Conclusions:

  • A novel NP928-loaded hyaluronic acid hydrogel provides an improved delivery system for dental pulp regeneration.
  • This combination therapy effectively stimulates reparative dentine formation.
  • The developed therapeutic procedure is suitable for general dental practice.