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Body segments and growth hormone.

R Bundak¹, P C Hindmarsh, C G Brook

¹University of Istanbul, Institute of Child Health, Turkey.

Archives of Disease in Childhood

|July 1, 1988

Summary

Five-year human growth hormone treatment equally improved sitting height and leg length in children with growth hormone deficiency. This finding is crucial for understanding growth responses in conditions like skeletal dysplasias.

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Area of Science:

Pediatric Endocrinology
Growth and Development
Biomedical Research

Background:

Children with isolated growth hormone deficiency exhibit impaired linear growth.
Understanding the differential effects of growth hormone on body segments is crucial for treatment optimization.
Previous studies have not comprehensively assessed long-term effects on specific body segment proportions.

Purpose of the Study:

To investigate the five-year effects of human growth hormone (hGH) treatment on sitting height and subischial leg length in prepubertal children.
To determine if different body segments respond uniformly to hGH therapy.
To provide insights for growth hormone's role in conditions affecting skeletal growth.

Main Methods:

A longitudinal study involving 35 prepubertal children with isolated growth hormone deficiency.
Treatment with human growth hormone administered over a five-year period.
Measurement of sitting height and subischial leg length at baseline and annually.

Main Results:

Human growth hormone treatment led to significant increases in both sitting height and subischial leg length.
Both body segments demonstrated an equal response to the five-year hGH treatment.
The proportional growth of the trunk and legs remained consistent during treatment.

Conclusions:

Five-year human growth hormone treatment promotes balanced linear growth in children with isolated growth hormone deficiency.
The equal response of sitting height and subischial leg length suggests a systemic effect of hGH on skeletal growth.
These findings have implications for managing growth disturbances in conditions such as skeletal dysplasias and post-spinal irradiation growth impairment.

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