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Blood coagulation parameter abnormalities in hospitalized patients with confirmed COVID-19 in Ethiopia

Shambel Araya1,2, Mintesnot Aragaw Mamo1,2, Yakob Gebregziabher Tsegay3,4

  • 1Department of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Plos One
|June 21, 2021
PubMed

Insights

Coagulopathy is common in COVID-19 patients, with over 50% of severe cases showing prolonged prothrombin time and elevated INR. Monitoring coagulation parameters is crucial for hospitalized patients, especially those over 55.

Area of Science:

  • Medical Research
  • Infectious Diseases
  • Hematology

Background:

  • Coagulopathy and thromboembolic events are recognized complications of Corona Virus disease 2019 (COVID-19).
  • Abnormal coagulation parameters serve as critical prognostic indicators for COVID-19 disease severity.
  • Understanding these coagulation abnormalities in diverse populations is essential for effective patient management.

Purpose of the Study:

  • To investigate and analyze the coagulation profiles of hospitalized COVID-19 patients in Addis Ababa, Ethiopia.
  • To identify specific coagulation abnormalities associated with COVID-19 severity.
  • To provide data that can inform clinical monitoring and treatment strategies.

Main Methods:

  • A prospective cross-sectional study involving 455 COVID-19 patients admitted to a care center in Addis Ababa, Ethiopia.
  • Coagulation parameters including Prothrombin Time (PT), Activated Partial Thromboplastin Time (APTT), and International Normalized Ratio (INR) were measured.
  • Statistical significance was defined as p<0.05.

Main Results:

  • Prolonged prothrombin time was observed in 46.8% of all COVID-19 patients.
  • Over 50% of severe and critical COVID-19 patients exhibited prolonged prothrombin time and elevated INR.
  • Thrombocytopenia affected 22.1% of patients, with higher prevalence (50.5%) in those over 55 years old, who also showed a higher incidence of prolonged APTT (51.3%).

Conclusions:

  • Prolonged PT and elevated INR are prevalent in severe and critical COVID-19 cases.
  • Thrombocytopenia and prolonged APTT are particularly noted in COVID-19 patients over 55 years of age.
  • Continuous monitoring of platelet count, PT, APTT, and INR is recommended for hospitalized COVID-19 patients.
Abstract

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