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Regulatory noncoding RNAs: functions and applications in health and disease
1Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal.
Abstract:
Science is facing a new RNA world that is shaping our knowledge, and we are discovering a new horizon in molecular biology. New technologies revealed thousands and thousands of new RNAs, most of them located in what was once known as the "dark matter of DNA". They are functional regulatory RNAs and do not code for proteins, and they orchestrate the cellular function according to the changes needed. These noncoding RNAs are ubiquitous, and they are present from viruses to humans. In this Virtual Issue, The FEBS Journal features a collection of recent articles on long noncoding RNAs, microRNAs, and circular RNAs. It gives a broad perspective regarding their role in vascular diseases, ocular diseases, immune cell development and homeostasis, inflammation, production of extracellular matrix, and cancer. Furthermore, review-type articles highlight the potential use of noncoding RNAs in a wide range of applications.
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lncRNA - Long Non-coding RNAs
lncRNA - Long Non-coding RNAs
Types of RNA
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Types of RNA
RNA Performs Diverse...
Translational Regulation
Regulation of Expression at Multiple Steps

