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Angiopoietin-like proteins in atherosclerosis
Yi-Zhang Liu1, Chi Zhang2, Jie-Feng Jiang1
1Research Laboratory of Translational Medicine, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, People's Republic of China; Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, People's Republic of China; Departments of Clinical Medicine, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, People's Republic of China.
Summary
Angiopoietin-like (ANGPTL) proteins are implicated in atherosclerosis, contributing to arterial wall inflammation and disease progression. Targeting ANGPTL3, ANGPTL4, and ANGPTL8 offers potential therapeutic strategies for atherosclerosis.
Area of Science:
- Cardiovascular Biology
- Molecular Medicine
- Inflammation Research
Background:
- Atherosclerosis is a major global health burden, characterized by chronic arterial wall inflammation.
- Emerging evidence links angiopoietin-like (ANGPTL) proteins to key pathological processes in atherosclerosis, including endothelial dysfunction, dyslipidemia, and inflammation.
Purpose of the Study:
- To review the current understanding of the ANGPTL protein family's role in atherosclerosis.
- To explore the potential of ANGPTL proteins as predictive biomarkers for atherosclerosis.
- To discuss ANGPTL-targeted therapies for atherosclerosis.
Main Methods:
- Literature review of studies investigating ANGPTL proteins and atherosclerosis.
- Analysis of ANGPTL involvement in endothelial dysfunction, inflammation, dyslipidemia, calcification, foam cell formation, and platelet activation.
- Evaluation of ANGPTL3, ANGPTL4, and ANGPTL8 roles in regulating lipoprotein lipase (LPL).
Main Results:
- ANGPTL proteins contribute to atherosclerosis through multiple pathological mechanisms.
- Specific ANGPTL members (ANGPTL3, ANGPTL4, ANGPTL8) play a significant role in atherosclerotic dyslipidemia by modulating LPL activity.
- ANGPTL proteins show potential as predictive biomarkers for atherosclerosis.
Conclusions:
- The ANGPTL protein family is critically involved in the pathogenesis of atherosclerosis.
- Targeting ANGPTL3, ANGPTL4, and ANGPTL8, particularly through antisense oligonucleotides or monoclonal antibodies, represents a promising therapeutic avenue for atherosclerosis.
- Further research into ANGPTL proteins could lead to novel diagnostic and therapeutic strategies for cardiovascular disease.
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