Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

49
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
49
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

472
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
472
Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding01:15

Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding

388
Enteral nutrition encompasses various methods of delivering nutrition directly to the gastrointestinal (GI) tract, bypassing traditional oral intake. It is particularly beneficial for patients who cannot eat by mouth but have a functioning digestive system. Key methods include nasointestinal feeding, gastrostomy, and jejunostomy, each suited to different clinical scenarios based on the patient's needs and condition.
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
388
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

55
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
55

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Motor and cognitive outcomes in pediatric intestinal failure: A longitudinal cohort study.

Intestinal Failure (New York, N.Y.)·2026
Same author

The impact of international care networks on the clinical management of constitutional mismatch repair deficiency (CMMRD): a review of recent developments.

Familial cancer·2026
Same author

Playing CATCH-up: a case report of profound protein-losing enteropathy and gastrointestinal haemorrhage from intestinal lymphangiectasia in DiGeorge syndrome.

European heart journal. Case reports·2026
Same author

Intestinal transplantation in Australia: Progress, challenges and future directions.

Internal medicine journal·2026
Same author

Wet beriberi in intestinal failure due to change from intravenous to enteral supplementation - Time to focus on water-soluble vitamins.

Intestinal Failure (New York, N.Y.)·2026
Same author

Physical function, physical activity, muscle strength, and body composition: Clinical practice recommendations in pediatric intestinal failure and transplantation-position statement of the International Intestinal Rehabilitation and Transplant Association Allied Health Committee.

Intestinal Failure (New York, N.Y.)·2026
Same journal

Standardized Mean Differences Reveal Substantial Selection Bias in Post-Reduction Management of Intussusception.

The Journal of pediatrics·2026
Same journal

Parenteral Lipid Dose and Bilirubin Neurotoxicity in Extremely Preterm Infants: A Factorial Randomized Trial.

The Journal of pediatrics·2026
Same journal

Refining Oxygen-Carrying Capacity Metrics in Assessing Mortality Risk from Pneumonia in Children.

The Journal of pediatrics·2026
Same journal

Time-to-Transfer and Hospitalization Duration for Severe Congenital Heart Defects: Implications for Perinatal Regionalization.

The Journal of pediatrics·2026
Same journal

Multimodal neuromonitoring in neonatal hypoxic-ischemic encephalopathy and the association with neurodevelopmental outcomes: A Multicenter Study.

The Journal of pediatrics·2026
Same journal

KP.2-Adapted BNT162b2 COVID-19 Vaccine Uptake and Effectiveness in Children.

The Journal of pediatrics·2026
See all related articles

Related Experiment Video

Updated: Nov 1, 2025

Tissue Engineering of the Intestine in a Murine Model
08:45

Tissue Engineering of the Intestine in a Murine Model

Published on: December 1, 2012

15.2K

Trends in Pediatric Intestinal Failure: A Multicenter, Multinational Study.

Daniela Gattini1, Amin J Roberts2, Paul W Wales3

  • 1Group for Improvement of Intestinal Function and Treatment, Transplant Centre, Toronto, Ontario, Canada; Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

The Journal of Pediatrics
|June 21, 2021
PubMed
Summary
This summary is machine-generated.

Outcomes for children with intestinal failure show decreased death and transplant rates, but enteral autonomy has not improved. More parenteral nutrition dependence necessitates new strategies for better patient outcomes.

Keywords:
enteral autonomyintestinal failureintestinal transplantation

More Related Videos

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
09:36

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers

Published on: July 28, 2022

2.4K
Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model
06:51

Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model

Published on: July 28, 2023

1.5K

Related Experiment Videos

Last Updated: Nov 1, 2025

Tissue Engineering of the Intestine in a Murine Model
08:45

Tissue Engineering of the Intestine in a Murine Model

Published on: December 1, 2012

15.2K
Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
09:36

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers

Published on: July 28, 2022

2.4K
Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model
06:51

Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model

Published on: July 28, 2023

1.5K

Area of Science:

  • Pediatric Gastroenterology
  • Intestinal Failure Research
  • Clinical Outcomes Analysis

Background:

  • Pediatric intestinal failure (IF) affects numerous children, necessitating long-term parenteral nutrition (PN) and posing significant risks.
  • Understanding the natural history and factors influencing outcomes in IF is crucial for improving patient care.
  • Contemporary data on IF outcomes are limited, especially from diverse, multicenter cohorts.

Purpose of the Study:

  • To evaluate the natural history and outcomes of children diagnosed with intestinal failure.
  • To identify factors associated with achieving enteral autonomy, requiring transplantation, or death.
  • To analyze trends in IF outcomes within a large, multicenter cohort from 2010-2015.

Main Methods:

  • Retrospective analysis of 443 children with intestinal failure across 6 pediatric IF programs.
  • Competing-risk analysis to determine cumulative incidence of enteral autonomy, transplantation, and death.
  • Bivariate and multivariable analyses using chi-squared tests and Cox proportional hazard regression.

Main Results:

  • Short bowel syndrome (SBS) was the primary diagnosis in 84.9% of patients.
  • At 6 years, cumulative incidences were 53.0% for enteral autonomy, 16.7% for transplantation, and 10.5% for death.
  • Enteral autonomy was linked to SBS, adequate small bowel length, ileocecal valve presence, and absence of portal hypertension.

Conclusions:

  • While death and transplantation rates have declined, significant progress in achieving enteral autonomy for children with IF has not been observed.
  • A growing proportion of IF patients remain dependent on parenteral nutrition, highlighting a critical unmet need.
  • Novel therapeutic strategies are essential to enhance enteral autonomy rates and improve long-term outcomes for children with intestinal failure.