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Updated: Nov 1, 2025

Production of Nanofibrillar Patterned Collagen for Tissue Engineering
Published on: September 20, 2024
Dense fibrillar collagen matrices for tissue repair
Marie Madeleine Giraud Guille1, Christophe Helary1, Sylvain Vigier1
1University Pierre and Marie Curie-Paris 6, Ecole Pratique des Hautes Etudes, CNRS-UMR 7574, Laboratoire Chimie de la Matière Condensée de Paris, 4 place Jussieu, 75005, Paris, France. mmgiraud@snv.jussieu.fr.
Abstract:
The preparation of dense fibrillar collagen matrices, through a sol/gel transition at variable concentrations, offers routes to produce a range of simple, non toxic materials. Concentrated hydrogels entrapping cells show enhanced properties in terms of reduced contraction and enhanced cell proliferation . Dense fibrillar matrices attain tissue like mechanical properties and show ultrastructures described in connective tissues, namely liquid crystalline cholesteric geometries. Their colonization by cells and possible association with a mineral phase in a tissue like manner validate their use as biomimetic materials for regenerative medicine.
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